|
KMID : 0545120130230081070
|
|
Journal of Microbiology and Biotechnology
2013 Volume.23 No. 8 p.1070 ~ p.1075
|
|
|
Effect of the Antimicrobial Peptide D-Nal-Pac-525 on the Growth of Streptococcus mutans and Its Biofilm Formation
|
|
Huajun Li
Jya-Wei Cheng
Hui-Yuan Yu
Yi Xin
Li Tang
Yufang Ma
|
|
|
Abstract
|
|
|
|
Streptococcus mutans is the primary etiological agent of dental caries. The antimicrobial peptide D-Nal-Pac-525 was designed by replacing the tryptophans of the Trp-rich peptide Pac-525 with D-β-naphthyalanines. To assess the effect of D-Nal-Pac-525 on cariogenic bacteria, the activity of D-Nal-Pac-525 on the growth of S. mutans and its biofilm formation were examined. D-Nal- Pac-525 showed robust antimicrobial activity against S. mutans (minimum inhibitory concentration of 4 μg/ml). Using scanning electron microscopy and transmission electron microscopy, it was shown that D-Nal-Pac-525 caused morphological changes and damaged the cell membrane of S. mutans. D-Nal-Pac-525 inhibited biofilm formation of S. mutans at 2 μg/ml. The results of this study suggest that D-Nal-Pac-525 has great potential for clinical application as a dental caries-preventing agent.
|
|
|
KEYWORD
|
|
|
antimicrobial peptides, Streptococcus mutans, biofilm, D-Nal-Pac-525
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|